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| موضوع: Free fatty acids الأحد ديسمبر 26, 2010 4:47 pm | |
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Free fatty acids (FFA) travel through the blood combined with albumin and in this form are called non-esterified fatty acids (NEFA). Normally, approximately three fatty acid molecules are combined with each molecule of albumin. If, however, the need for fatty acid transport is great (e.g., when needed carbohydrates are not available or cannot be used for energy), as many as 30 fatty acids can combine with one albumin molecule. Thus, although blood levels of FFA are never very high, they rise impressively after stimuli to release fat. The same stimuli that elevate FFA will, in most cases, also elevate serum triglycerides and may produce alterations in lipoprotein levels. Reference Values
Free fatty acids 8–25 mg/dL INTERFERING FACTORS
Ingestion of alcohol within 24 hours before the test may result in falsely elevated values.
Failure to follow dietary restrictions before the test may alter values.
Drugs known to alter FFA levels should not be ingested unless the test is being performed to evaluate such effects INDICATIONS FOR FREE FATTY ACIDS TEST
Support for diagnosing uncontrolled or untreated diabetes mellitus, as indicated by elevated levels
Evaluation of response to treatment for diabetes, as indicated by declining levels
Suspected malnutrition, as indicated by elevated levels
Known or suspected disorder associated with excessive hormone production as indicated by elevated levels
Evaluation of response to therapy with drugs known to alter FFA levels
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